Palmieri served as communications director for former President Barack Obama from 2011 to 2015. Previously, she served as president of the Center for American Progress Action Fund. Palmieri also served as director of communications for Hillary Clinton’s 2016 presidential campaign and as national press secretary for John Edwards’ 2004 presidential campaign. She is the author of “She Proclaims: Our Declaration of Independence from a Man's World,” published in 2020.